Profil Kadar Natrium Serum pada Pemberian Manitol 20% dan Natrium Laktat Hipertonik Intravena pada Tikus Jantan Wistar

Background and Objective: Prolonged use of hyperosmolar solution associated with mortality. Hypertonic sodium lactate as a new sodium-based does not yet have an evidence base that states long-term is safe in increasing ICP. Knowing the effect hypertonic on alterations level male wistar rats compared to mannitol Subject Method: This research animal experimental laboratory study using simple random sampling design.Thirtysix were obtained age body weight 14.22±0.43 weeks 301.56±25.10gr group A 14.17±0.38 277.61±18.85gr B. Both groups given or for 5 days assessed changes after administration. Results: The highest levels occurred first day 5.06±4.25 before treatment 5.67±2.96 mEq / L (p = 0.222) lowest at third second (0.22±3.51 vs 0.22±2.29 L) 0.568). mean was 147.83±3.35 145.83±2.07 146.06±2.92. Conclusion: In this study, increased significantly treatment, but followed by significant fifth day.